Liverpool ended their campaign with a comfortable win in which Sami Hyypia appeared as a substitute late on in his final appearance for the Anfield club.
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Sunderland were beaten by Chelsea but avoided relegation as their rivals did not get the results to overtake them.
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Robin van Persie scored twice as Arsenal ended their season with 4-1 victory over Stoke City.
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Newcastle’s 16-year stay in the Premier League was ended in limp fashion as Damien Duff’s own goal consigned them to a devastating defeat at Aston Villa.
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Leon Osman’s two goals secured victory for Everton, who also sealed fifth-place in the Premier League.
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Manchester City ended the season on a high after Felipe Caicedo’s eighth goal of the season made the difference in this mid-table encounter.
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Antonio Valencia, who is expected to leave Wigan this summer, has been nursing a hamstring injury and is unlikely to play against Pompey.
Watch this English Premier League match, Wigan Vs Portsmouth highlights here.
Venue: JJB Stadium
Date: Sunday, 24 May
Kick-off: 1600 BST
Middlesbrough’s 11-year stay in the Premier League came to a halt at Upton Park after Gareth Southgate’s side lost rather limply to West Ham.
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Blackburn and West Bromwich Albion played out a goalless draw that had an end-of-season-feel written all over it.
Venue: Ewood Park
Date: Sunday, 24 May
Kick-off: 16:00 BST
Sunderland remain in serious danger of relegation after relinquishing a one-goal lead to lose at Portsmouth.
The visitors took the lead against the run of play when Calum Davenport’s cross was tapped in by Kenwyne Jones.
John Utaka fired in an equaliser a minute later and then forced Phil Bardsley to bundle in an own goal that gave the home side the lead.
Sunderland’s woe was sealed late on when Utaka found substitute Armand Traore and he fired in an angled shot.
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West Brom were relegated from the Premier League after being beaten by Liverpool at the Hawthorns.
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Nicolas Anelka set up one goal and scored another as Chelsea strolled past Blackburn in manager Guus Hiddink’s final match at Stamford Bridge.
Blackburn were one off the foot when Sam Allardyce took over. They will finish in a comfortable mid-table position.
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Manchester United sealed a third successive Premier League title by getting the point they needed against Arsenal – but the Old Trafford celebrations only started after an afternoon gripped by tension.
Man Utd wrap up their third consecutive Premier League title after a 0-0 draw with Arsenal at Old Trafford.
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A late penalty from Tottenham striker Robbie Keane extinguished Manchester City’s European hopes despite a brave rearguard action by the visitors.
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Louis Saha scored twice as Everton came from behind against 10-men West Ham to end the visitors’ Europa League hopes.
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Middlesbrough’s Premier League status was left hanging by a thread after John Carew equalised Tuncay Sanli’s opener to earn Aston Villa a deserved draw.
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Newcastle’s Premier League future hangs in the balance after Diomansy Kamara’s strike gave Fulham victory.
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Goals from Ricardo Fuller and James Beattie gave Stoke a comfortable win which saw them move above Wigan and into 11th in the Premier League table.
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Hull were denied a win by the heroics of Bolton keeper Jussi Jaaskelainen as they had to settle for a draw which moves them out of the relegation zone.
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